Divide a large drawing into multiple smaller drawings and then attach them into a master drawing (see About Attaching and Detaching Referenced Drawings (Xrefs)).

Use the JOIN command to combine small line segments.

Use the BLOCK command to combine and replace repeating objects or groups of line segments.

Use the WBLOCK command to resave parts or the entire drawing (see Export objects to a drawing file with WBLOCK command).

Use SAVEAS to save a new file or save overtop of the original.

Enter the FILTERS command and delete layer filters.

Enter the -SCALELISTEDIT command and reset the scale list.

Enter the PURGE command and select all options.

Enter the -PURGE command and choose Regapps.

Select all objects in a drawing and enter the OVERKILL command.

Detach all unneeded xref files using the XREF command.

Solution: Use the following commands to reduce the size of a DWG file.

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